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Pediatric Treatment Editorial Board. Patients had significantly lower pre-RT concentrations of B, Cu, and Zn, and significantly higher concentrations of Sr than the control group. Irradiation was associated with a striking increase in plasma B concentrations, while Cu, Fe, Sr and Zn concentrations were not significantly different from pre-RT levels, albeit Sr and Zn showed non-significant trends towards increases. The plasma concentrations of B, Cu, Fe, Sr, and Zn were associated with the tumor expression of hormone receptors, epidermal growth factor receptor 2, Ki67 antigen, as well as dermatitis and asthenia, all of which represent the main toxicological responses to RT.

Keywords: Breast cancer; Metals; Radiation therapy; Trace elements. Abstract Alterations in the circulating levels of trace elements have been observed in breast cancer BC patients.

Substances Biomarkers, Tumor Trace Elements.



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